Julia Arciero

Assistant Professor
Department of Mathematical Sciences
Indiana University-Purdue University Indianapolis

Address:	Department of Mathematical Sciences School of Science Indiana University-Purdue University Indianapolis 402 N. Blackford St. LD 270D Indianapolis, IN 46202
Phone:	(317) 274-6998
E-Mail:	jarciero@math.iupui.edu
Office:	LD 270D
Office Hours:	Tuesday 3-4 pm and Wednesday 2-3 pm (in LD 270D) or by appointment

Teaching:

IUPUI

Spring 2012:
MATH 426 : Introduction to Applied Mathematics and Modeling

Fall 2011:
MATH S-165 : Honors Calculus 1

University of Pittsburgh

MATH 0290 : Applied Differential Equations

MATH 0230 : Analytic Geometry & Calculus 2

MATH 0290 : Applied Differential Equations

MATH 0240 : Analytic Geometry & Calculus 3

MATH 0230 : Analytic Geometry & Calculus 2

MATH 0220 : Analytic Geometry & Calculus 1

University of Arizona

MATH 111.006 : Trigonometry

MATH 111.004 : Trigonometry

Publications:

1. Arciero JC and Secomb TW. Spontaneous oscillations in a model for active control of microvessel diameters. Math Med Biol. doi: 10.1093/imammb/dqr005, 2011

2. Arciero JC, Mi Q, Branca MF, Hackam DJ, Swigon D. Continuum Model of Collective Cell Migration in Wound Healing and Colony Expansion. Biophysical Journal. 100:1-9, 2011

3. Arciero JC, Ermentrout GB, Upperman JS, Vodovotz Y, Rubin JE. Using a Mathematical Model to Analyze the Role of Probiotics and Inflammation in Necrotizing Enterocolitis. PLoS ONE 5(4): e10066. doi:10.1371/journal.pone.0010066, 2010

4. Arciero JC, Begg R, Wilkie K, et al. A Mechanism for Ventricular Expansion in Communicating Hydrocephalus. Proceedings of the OCCAM-Fields-MITACS Biomedical Problem Solving Workshop, 2009

5. Arciero, JC, Carlson, BE, Secomb, TW. Theoretical model of metabolic blood flow regulation: roles of ATP release by red blood cells and conducted responses. Am J Physiol Heart Circ Physiol 295: H1562-H11571, 2008.

6. Carlson, BE, Arciero, JC, Secomb, TW. Theoretical model of blood flow autoregulation: Roles of myogenic, shear-dependent and metabolic responses. Am J Physiol Heart Circ Physiol 295: H1572-H1579, 2008.

7. Arciero, JC, Jackson, TL, Kirschner, DE. A mathematical model of tumor immune evasion and siRNA treatment. Discrete Contin. Dynam. Sys. 4(1):39-58, 2004.

Research:

Indiana University-Purdue University, Indianapolis:
As an assistant professor, my research interests lie primarily in mathematical biology. I am particularly interested in developing models that address problems that involve components of the circulatory system and inflammation, as in wound healing and necrotizing enterocolitis. I am also interested in modeling autoregulation in the eye and will investigate additional problems in the vasculature.

University of Pittsburgh:
In my postdoctoral work, I was a member of the Complex Biological Systems Group in Pitt's Department of Mathematics and developed theoretical models to investigate an inflammatory disease of the gut called necrotizing enterocolitis (NEC), which affects premature infants. NEC is thought to be related to an immature intestinal wall, an exaggerated inflammatory response, and impaired cell migration. I have studied the contributions of these factors to NEC using two models: a compartmental ODE model that predicts conditions under which probiotic bacterial treatment may promote health (joint work with Bard Ermentrout, Jonathan Rubin, Yoram Vodovotz, and David Hackam's lab) and a two-dimensional continuum mechanical model of collective cell migration (joint work with David Swigon and Qi Mi).

University of Arizona:
In my doctoral work, I developed a mechanistic model of blood flow regulation in microvascular networks of skeletal muscle. In addition to modeling vascular responses to pressure and shear stress, I modeled a conducted response mechanism in which ATP released by red blood cells at a site of oxygen demand causes an electrical signal to travel upstream along the vessel wall and trigger arteriolar vasodilation so that more blood is sent to the region of demand. Our representative segment ODE model was based on the active and passive length-tension characteristics of vascular smooth muscle and was used to calculate the steady state vessel diameter and smooth muscle tone as oxygen consumption was increased from a resting to maximal exercise state. The model predicted an increase in flow that was consistent with experimental observations. I also examined the model's predictions of limit cycle oscillations in vessel diameter as a potential mechanism for vasomotion. (Ph.D. Advisor: Dr. Timothy Secomb)

University of Michigan:
As an undergraduate, I worked on an REU (Research Experience for Undergraduates) with Dr. Trachette Jackson in the area of mathematical modeling of cancer. We developed a five-dimensional system of ODEs to examine the growth, immune escape, and siRNA treatment of tumors.