Julia Arciero

Assistant Professor
Department of Mathematical Sciences
Indiana University-Purdue University Indianapolis

Address:	Department of Mathematical Sciences School of Science Indiana University-Purdue University Indianapolis 402 N. Blackford St. LD 270D Indianapolis, IN 46202
Phone:	(317) 274-6998
E-Mail:	jarciero@math.iupui.edu
Office:	LD 270D
Office Hours:	Monday 3-4:30 pm and Wednesdays 9:30-10:30am and 3-4 pm (in LD 270D) or by appointment

Teaching:

IUPUI

Spring 2013:
    MATH 266 : Differential Equations

    MATH 426 : Introduction to Applied Mathematics and Modeling

Fall 2012:
    MATH S-165 : Honors Calculus I

    MATH 221 : Calculus for Technology I

Spring 2012:
    MATH 426 : Introduction to Applied Mathematics and Modeling

Fall 2011:
    MATH S-165 : Honors Calculus 1

University of Pittsburgh

MATH 0290 : Applied Differential Equations

MATH 0230 : Analytic Geometry & Calculus 2

MATH 0290 : Applied Differential Equations

MATH 0240 : Analytic Geometry & Calculus 3

MATH 0230 : Analytic Geometry & Calculus 2

MATH 0220 : Analytic Geometry & Calculus 1

University of Arizona

MATH 111.006 : Trigonometry

MATH 111.004 : Trigonometry

Publications:

13. Arciero JC, Harris A, Siesky B, Amireskandari A, Gershuny V, Pickrell A, Guidoboni G. Theoretical analysis of vascular regulatory mechanisms contributing to retinal blood flow autoregulation, IOVS (submitted 2012)

12. Harris A, Guidoboni G, Arciero JC, Amireskandari A, Tobe L, Siesky BA. Ocular Hemodynamics and Glaucoma: The Role of Mathematical Modeling, European Journal of Ophthalmology (accepted 2012)

11. Arciero JC, Ermentrout GB, Siggers R, Afrazi A, Hackam D, Vodovotz Y, Rubin, J. Modeling the interactions of bacteria, the immune response, and Toll-like receptors in necrotizing enterocolitis. Journal of Theoretical Biology. (accepted 2012)

10. Arciero JC, Mi Q, Branca M, Hackam D, Swigon D. Using a continuum model to predict closure time of wounded intestinal epithelial cell layers. Wound Repair and Regeneration. (accepted 2012)

9. Arciero JC, Swigon D. "Equation-based modeling of wound healing and collective cell migration" in Complex Systems and Computational Biology Approaches to Acute Inflammation. Springer Science+Business Media. (submitted 2012)

8. Arciero JC, Barber JB, Kim M. "Modeling host-pathogen interactions in necrotizing enterocolitis" in Complex Systems and Computational Biology Approaches to Acute Inflammation. Springer Science+Business Media. (submitted 2012)

7. Arciero JC and Secomb TW. Spontaneous oscillations in a model for active control of microvessel diameters. Math Med Biol. doi: 10.1093/imammb/dqr005, 2011

6. Arciero JC, Mi Q, Branca MF, Hackam DJ, Swigon D. Continuum Model of Collective Cell Migration in Wound Healing and Colony Expansion. Biophysical Journal. 100:1-9, 2011

5. Arciero JC, Ermentrout GB, Upperman JS, Vodovotz Y, Rubin JE. Using a Mathematical Model to Analyze the Role of Probiotics and Inflammation in Necrotizing Enterocolitis. PLoS ONE 5(4): e10066. doi:10.1371/journal.pone.0010066, 2010

4. Arciero JC, Begg R, Wilkie K, et al. A Mechanism for Ventricular Expansion in Communicating Hydrocephalus. Proceedings of the OCCAM-Fields-MITACS Biomedical Problem Solving Workshop, 2009

3. Carlson, BE, Arciero, JC, Secomb, TW. Theoretical model of blood flow autoregulation: Roles of myogenic, shear-dependent and metabolic responses. Am J Physiol Heart Circ Physiol 295: H1572-H1579, 2008.

2. Arciero, JC, Carlson, BE, Secomb, TW. Theoretical model of metabolic blood flow regulation: roles of ATP release by red blood cells and conducted responses. Am J Physiol Heart Circ Physiol 295: H1562-H11571, 2008.

1. Arciero, JC, Jackson, TL, Kirschner, DE. A mathematical model of tumor immune evasion and siRNA treatment. Discrete Contin. Dynam. Sys. 4(1):39-58, 2004.

Research:

Indiana University-Purdue University, Indianapolis:
As an assistant professor, my research interests lie primarily in mathematical biology. I am currently developing a mathematical model to assess the significance of changes in vascular segments subsequent to a major arterial occlusion based upon data obtained from the mouse hindlimb (Collaborators: Joseph Unthank (IUSM), George Akingba (IUSM), Matt DiStasi, (IUSM); Students: Malorie Kennedy and Stephanie Willoughby). I am also using a mathematical model to predict the relative importance of regulatory mechanisms in achieving retinal autoregulation (Collaborators: Giovanna Guidoboni (IUPUI), Alon Harris (IUSM), Brent Siesky (IUSM)). I have begun to develop a mathematical model of the immune-mediated rejection of pancreatic islet transplants (Collaborator: Giorgio Raimondi (University of Pittsburgh); Student: Andrew Maturo (IUPUI)). Finally, I am designing an enzyme kinetics model to predict the time course and reaction products of a catalyzed reduction of Chalcone (Collaborators: Tyler Nguyen (IUSM) and Ryan Denton (IUPUI).

University of Pittsburgh:
In my postdoctoral work, I was a member of the Complex Biological Systems Group in Pitt's Department of Mathematics and developed theoretical models to investigate an inflammatory disease of the gut called necrotizing enterocolitis (NEC), which affects premature infants. NEC is thought to be related to an immature intestinal wall, an exaggerated inflammatory response, and impaired cell migration. I have studied the contributions of these factors to NEC using two models: a compartmental ODE model that predicts conditions under which probiotic bacterial treatment may promote health (joint work with Bard Ermentrout, Jonathan Rubin, Yoram Vodovotz, and David Hackam's lab) and a two-dimensional continuum mechanical model of collective cell migration (joint work with David Swigon and Qi Mi).

University of Arizona:
In my doctoral work, I developed a mechanistic model of blood flow regulation in microvascular networks of skeletal muscle. In addition to modeling vascular responses to pressure and shear stress, I modeled a conducted response mechanism in which ATP released by red blood cells at a site of oxygen demand causes an electrical signal to travel upstream along the vessel wall and trigger arteriolar vasodilation so that more blood is sent to the region of demand. Our representative segment ODE model was based on the active and passive length-tension characteristics of vascular smooth muscle and was used to calculate the steady state vessel diameter and smooth muscle tone as oxygen consumption was increased from a resting to maximal exercise state. The model predicted an increase in flow that was consistent with experimental observations. I also examined the model's predictions of limit cycle oscillations in vessel diameter as a potential mechanism for vasomotion. (Ph.D. Advisor: Dr. Timothy Secomb)

University of Michigan:
As an undergraduate, I worked on an REU (Research Experience for Undergraduates) with Dr. Trachette Jackson in the area of mathematical modeling of cancer. We developed a five-dimensional system of ODEs to examine the growth, immune escape, and siRNA treatment of tumors.