Basal Ganglia dynamics vs. Basal Ganglia function and dysfunction

informal workshop

at the annual Computational Neuroscience Meeting CNS*2008

July 23, 2008

Oregon Health Sciences University Center for Health and Healing, Portland, OR

(Center for Health and Healing, CHH 3rd floor, Jul 23 AM sessioin)


Leonid Rubchinsky (, Indiana University Purdue University Indianapolis and Indiana University School of Medicine

Arthur Leblois (, University of Washington


The basal ganglia (BG) have been shown to be involved in a wide range of motor, cognitive and limbic processes, while their dysfunction is known to be responsible for many neurological diseases, including Parkinson's and Huntington's diseases. The dynamics of single neurons as well as population activity in BG circuits have been studied extensively both in normal and pathological conditions. In particular, recent studies have evidenced and characterized various patterns of oscillatory activity in these conditions, often synchronized within or between BG nuclei. However, the relationship between these neuronal dynamics and BG function and dysfunction remains quite uncertain.

During this workshop, we will discuss controversial relationship between dynamics of BG neurons and circuits, functional aspects related to motor control and cognitive programming (and also learning in a more broad perspective), and BG related disorders such as Parkinson's disease. We would especially like to highlight how computational methods for data analysis and modeling neuronal dynamics might help to reveal complicated relationship between function, dysfunction and neuronal dynamics. The aim of the workshop is to have an informal exchange of ideas. Those who have presentation at the main CNS meeting are welcomed to discuss their results with different, more speculative perspective.


                           List of Participants and Talks

Ramana Dodla (University of Texas, San Antonio)

    Synchrony-asynchrony transitions in neuronal networks


David Hunn (Arizona State University)

    Functional implications of dopamine-driven pattern recognition in striatum II


Arthur Leblois (University of Washington)

    Late emergence of synchronized oscillations during progressive Parkinsonism


Leonid Rubchinsky (Indiana University - Purdue University Indianapolis)

    Variability of basal ganglia oscillations and its possible relation to function


Stephen Helms Tillery (Arizona State University)

    Functional implications of dopamine-driven pattern recognition in striatum I


Lane Wallace (Ohio State University)